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DeCS
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Descriptor English:
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Gene Amplification
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Descriptor Spanish:
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Amplificación de Genes
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Descriptor Portuguese:
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Amplificação de Genes
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Synonyms English:
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Amplification, Gene
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Tree Number:
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G05.308.250
G05.365.590.310
G05.558.315
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Definition English:
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A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication. |
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Indexing Annotation English:
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for physiol process only; for technique use NUCLEIC ACID AMPLIFICATION TECHNIQUES or specifics
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Entry Combination - descr/qualif English:
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Gene Amplification/methods use Nucleic Acid Amplification Techniques
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See Related English:
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Gene Dosage
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History Note English:
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80
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Allowable Qualifiers English:
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Record Number:
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28047
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Unique Identifier:
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D005784
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Occurrence in VHL:
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Similar:
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DeCS
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